9,223 research outputs found

    The mutational meltdown in asexual populations

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    Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutations. This synergistic interaction between population size reduction and mutation accumulation leads to an extinction process known as the mutational meltdown, and provides a powerful explanation for the rarity of obligate asexuality. We give an overview of the theory of the mutational meltdown, showing how the process depends on the demographic properties of a population, the properties of mutations, and the relationship between fitness and number of mutations incurred

    Hierarchy of integrable Hamiltonians describing of nonlinear n-wave interaction

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    In the paper we construct an hierarchy of integrable Hamiltonian systems which describe the variation of n-wave envelopes in nonlinear dielectric medium. The exact solutions for some special Hamiltonians are given in terms of elliptic functions of the first kind.Comment: 17 page

    The effectiveness of functional family therapy in substance-involved family preservation clients

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    Abuse and neglect of children has been a recognized problem in America for many years. Recent developments in the child welfare system have introduced intensive, family-based services, otherwise known as family preservation services. The aim is to preserve the family and provide reasonable efforts to avoid out of home placement. State and private family preservation programs across the country have been faced with the challenge of evaluating program effectiveness and to better meet the needs of client populations by enhancing treatment models and programs; The Nevada State Division of Child and Family Services (DCFS) has utilized valuable resources to evaluate their Intensive Family Preservation (IFP) service program to discover its effectiveness. The program has been the subject of a longitudinal study. Research data from the 1999 fiscal year was used to examine the effectiveness of the Functional Family Therapy (FFT) model on substance-involved families. This secondary analysis discovered that the preservation services in Las Vegas are effective but that substance involved families have significantly lower outcome scores. The data revealed that substance-involved families also have larger households and less income than non-substance users

    Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis.

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    Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state with continued oxidative stress within the tissue. Reactive oxygen species and reactive nitrogen species produced by the immune and epithelial cells damage the host cells and can result in DNA damage. H pylori has evolved to evoke this damaging response while blunting the host's efforts to kill the bacteria. This long-lasting state with inflammation and oxidative stress can result in gastric carcinogenesis. Continued efforts to better understand the bacterium and the host response will serve to prevent or provide improved early diagnosis and treatment of gastric cancer

    Using Wave-Packet Interferometry to Monitor the External Vibrational Control of Electronic Excitation Transfer

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    We investigate the control of electronic energy transfer in molecular dimers through the preparation of specific vibrational coherences prior to electronic excitation, and its observation by nonlinear wave-packet interferometry. Laser-driven coherent nuclear motion can affect the instantaneous resonance between site-excited electronic states and thereby influence short-time electronic excitation transfer (EET). We first illustrate this control mechanism with calculations on a dimer whose constituent monomers undergo harmonic vibrations. We then consider the use of nonlinear wave-packet interferometry (nl-WPI) experiments to monitor the nuclear dynamics accompanying EET in general dimer complexes following impulsive vibrational excitation by a sub-resonant control pulse (or control pulse sequence). In measurements of this kind, two pairs of polarized phase-related femtosecond pulses following the control pulse generate superpositions of coherent nuclear wave packets in optically accessible electronic states. Interference contributions to the time- and frequency-integrated fluorescence signal due to overlaps among the superposed wave packets provide amplitude-level information on the nuclear and electronic dynamics. We derive the basic expression for a control-pulse-dependent nl-WPI signal. The electronic transition moments of the constituent monomers are assumed to have a fixed relative orientation, while the overall orientation of the complex is distributed isotropically. We include the limiting case of coincident arrival by pulses within each phase-related pair in which control-influenced nl-WPI reduces to a fluorescence-detected pump-probe difference experiment. Numerical calculations of pump-probe signals based on these theoretical expressions are presented in the following paper

    The role of the Fulbe in the urban life and economy of Lunsar, Sierra Leone: being a study of the adaptation of an immigrant group

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    In 1954 Dr. J. Littlejohn conducted a pilot survey of the town of Lunsar in Sierra Leone on behalf of the Department of Social Anthropology in the University of Edinburgh. Five years later, in May 1959 under the direction of Dr. K. L. Little, Dr. Littlejohn returned to Sierra Leone as leader of the University of Edinburgh, Lunsar Research Team. The other two team members at that time were Dr. D. Gamble (anthropologist) and Dr. R. Mills (physician). This team, generous- ly financed by the Nuffield Foundation, had the aim of studying the process of urbanisation in a town which had grown solely as a result of open cast iron mining activities taking place less than a mile away. During the course of his investi- gations Dr. Littlejohn reported that one tribal group, the Fula or Fulbe, were different from the other immigrants in that they kept separate from the other tribes, appeared to be strongly Muslim, and had defeated the Temne on a number of occasions in Historical times. It was recommended that I go to Lunsar and study the Fulbe to find out how they adapted themselves to living in Lunsar so that the Fulbe might be compared with the other tribal groups. An outline of techniques used in the study of the Fulbe is given below. Participant observation. This in itself is more of a way of life than a special technique, a kind of omnidirectional departure point from which the field worker gathers information by a number of means, viz: - a. observation and noting of the physical distribution and movement of the subjects of study. b. the interception by ear and eye of distribution and content of communications between subjects. c. the asking of direct and indirect questions to elucidate what has been seen or heard, or read as being the behaviour of the subjects. The taking up of a special identity, the effort of learning the language, the assumption of a local name, the sharing of food when offered and the other deli- berate acts of behaviour already mentioned are in fact 'participant observations' which are unstructured and can themselves only lead to impressions based on chance contacts. The study period in Lunsar was originally to be six months, although this was later extended to ten months. Clearly, to collect enough data within this time a very intensive study had to be conducted. Selection of informants. Since there were so few Fulbe in Lunsar it was important to obtain certain basic data on all the residents and as many Fulbe passing through Lunsar as possible. To assist in this an interview guide was drawn up which appears as an Appendix. From information gained in this way the demography and statistical structure of Lunsar and itinerant Fulbe was calculated. In analysis, all Fulbe who had stayed in Lunsar longer than nine months were treated as residents, and those staying for a shorter period were regarded as itinerants. This is a purely arbitrary division but no other could be adopted because of the unpredictability and high mobility of the Fulbe. Additional specialist information, for example on occupations, ritual and vi. family was obtained directly from the persons best able to provide the informa- tion. An attempt was made to avoid using one informant more than others. Pachometric Tests. The psychometric tests used were not intended to be anything more than a more exact way of verifying or refuting hypothesesmade on the basis of data obtained by observation and interview. Where the data from such tests appears in the text only a minimum of arithmetic appears, and the main calcula- tions appear separately in an appendix. Samples. The informants subjected to tests of one kind or another were not all selected at random. Although random samples may be ideal, especially when the distribution of variations in the population is known, they were found to be un- satisfactory because of the informant's' continuous coming and going as they went about their business, trailing, etc. Also, even if the population in Lunsar had been correctly represented, the total statistical universe of Fulbe all over Africa could not be. To get round this difficulty large samples were used (3 plus) stratified by age and occupation in as similar manner as possible as the total Lunsar Fulbe population. Also appearing as an appendix is a list of Fulbe informants in Lunsar and the tests set them. It will be noted that few women have been used in these special studies. This is because the Fulbe women although very independent are not considered by their menfolk as repositories of knowledge and wisdom. The women themselves act according to their society's expectations of them and consider intensive question- ing on topics other than domestic issues embarrassing and answer such questions by "mi anda" - I do not know. Documentary material. Although there is an enormous literature on the Fulbe, most of it takes its subject matter from areas dominated by Fulbe. Little has been written about the behaviour of Fulbe on the peripheries of these concentra- reemburs oÇ tions, where they are faced with the problem of interacting with ,(other cultures ulture, while maintaining their own c vii. A few articles on Fulbe in Sierra Leone have been written and where possible the relevant material has been incorporated in this study. Native Authority court records were consulted, although they reported few cases involving Fulbe. A far richer source of information way, the District Commissioner's files at Port Lokko, from which the history of political conflict since the war between Fulbe and the Temnes and Lokkos was in part obtained. Mechanical E uioment, a. A camera was used to obtain pictorial illustrations, some it of which appear in the text. However, it was found that /was very difficult to com- bine note taking and picture taking, so most photographs were taken on outings specifically assigned for this purpose. It was found that the best technique was to write down a list of the photographs required and systematically tick off each subject as it was photographed. when the social situation to be studied is out- side the control of the field worker, e.g. rituals, a decision has to be made at the time on whether notes or photographs will be of most use. When long sequen- ces of photographs can be taken and the films processed locally it is fairly easy to ask informants to explain them afterwards. b. A tape recorder was used to collect material at cere- monies, although for various reasons it did not work on some important occasions. The tape recorder was sometimes used during interviews when more than one informant was being used. This enabled me to find out afterwards what was discussed by people not actually talking to me at the time. c. General information on each informant was transferred on to 'Cope. Chat Paramount Punch Cards' to assist in the processing of statistical data. Each informant was given a code number on being first interviewed. This helped me to differentiate between a number of people with the same names. Each individuals card could also be sorted out by the code number. A complete descrip- tion of the card system and codes appearsin appendix D. This was written in the field so that in the event of an accident to myself, the material would be understandable to anyone else

    Breaking of the overall permutation symmetry in nonlinear optical susceptibilities of one-dimensional periodic dimerized Huckel model

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    Based on infinite one-dimensional single-electron periodic models of trans-polyacetylene, we show analytically that the overall permutation symmetry of nonlinear optical susceptibilities is, albeit preserved in the molecular systems with only bound states, no longer generally held for the periodic systems. The overall permutation symmetry breakdown provides a fairly natural explanation to the widely observed large deviations of Kleinman symmetry for periodic systems in off-resonant regions. Physical conditions to experimentally test the overall permutation symmetry break are discussed.Comment: 7 pages, 1 figur
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